If World War 3 ever erupted, certain U.S. locations could be far more at risk than others.

Military planners say that if nuclear weapons were ever used against the United States, the goal would not simply be to cause the most civilian casualties. Instead, the focus would be on weakening the country’s ability to respond. Strategic targets such as command centers, radar systems, and missile silos would likely be prioritized because they are key to military operations. As analysts explain, “disabling key defense infrastructure can often be more consequential than striking densely populated areas.” For this reason, intercontinental ballistic missile (ICBM) silos are considered especially important targets since they form a core part of the nation’s nuclear deterrent.

ICBM silos are one leg of the U.S. nuclear triad, alongside submarine-launched missiles and strategic bombers. These land-based missiles provide a rapid retaliatory capability designed to ensure the country can respond even after a nuclear strike. Most silos are located in remote areas across the Great Plains and Rocky Mountain region, a placement that reflects Cold War planning meant to keep them away from large cities while maintaining strategic coverage. However, if these sites were targeted, nuclear explosions could still bring major destruction and environmental damage to nearby communities and ecosystems.

Researchers have studied how radioactive fallout might spread if missile fields were attacked. Simulations, including those discussed in Scientific American, show that the heaviest contamination would occur near silo clusters in states such as Colorado, Wyoming, Nebraska, Montana, and North Dakota. Because nuclear blasts send radioactive debris high into the atmosphere, winds could carry particles “over hundreds, or even thousands, of miles,” spreading contamination far beyond the original targets.

A 2024 analysis identified Montana, Wyoming, Colorado, Nebraska, South Dakota, North Dakota, Iowa, and Minnesota as areas facing the highest potential radiation exposure in such a scenario. Some regions of the eastern United States might experience lower direct fallout because they are farther from missile fields, though they would still face indirect effects like economic disruption and contaminated resources.

Experts stress that no region would truly be safe. John Erath of the Center for Arms Control and Non-Proliferation warns that fallout can spread widely, damaging air, water, and agriculture. The broader lesson, analysts say, is clear: the consequences of nuclear conflict would be “global, indiscriminate, and profoundly enduring,” making prevention and deterrence the only reliable protection.

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