Less than two months before his death at 48, James Van Der Beek shared a warning that now feels especially urgent: “You can have no symptoms and still have cancer.” His message was simple—but powerful.

Colorectal cancer is one of the deadliest cancers worldwide. In 2020, about 930,000 people died globally. In the United States, projections for 2026 estimate 55,230 deaths, making it the second-leading cause of cancer-related deaths among men and women combined, according to the American Cancer Society.

In a 2024 interview with People, Van Der Beek revealed he had been diagnosed with stage 3 colorectal cancer at 46. He admitted he once linked cancer mainly to older age or unhealthy lifestyles—not to someone physically fit like himself.

His diagnosis followed subtle symptoms in 2023, including changes in bowel habits that he initially dismissed. When diet adjustments didn’t help, he chose to get checked. A colonoscopy confirmed the cancer. He later recalled going into shock, especially since he had felt relatively well.

Colorectal cancer can be difficult to detect early. Warning signs may include abdominal discomfort, fatigue, unexplained weight loss, rectal bleeding, or ongoing changes in bowel habits—but some people experience no noticeable symptoms at all.

Screening is widely recommended starting at age 45. Early detection greatly improves outcomes and may allow treatment through surgery, chemotherapy, or radiation if necessary.

In his final months, Van Der Beek emphasized awareness over sympathy. His message remains clear: don’t wait for serious symptoms—early testing can save lives.